Bio links, Fall 2025

I’d like to highlight some biological news that recently came out:ReprogeneticsImputePGTA from Herasight: estimating an embryo’s genotype based on very low coverage sequencing (as low as 70,000 reads, or ∼0.002x coverage!) given knowledge of the phased whole genome sequences of the embryo’s parents. Haplotype phasing is most effective if the embryo’s grandparents have also been sequenced. Since many IVF clinics offer PGT-A but not PGT-P, this will expand the number of people able to use polygeni...