Cancer-Selective, Pan-Essential Targets from DepMap

IntroductionBack in June, I proposed that it would be a good idea to look for broad-spectrum cancer treatments — i.e. therapies that work on many types of cancer, rather than being hyper-specialized for narrow subtypes. There’s nothing fantastic about this notion. After all, some of the oldest cancer treatments (chemotherapy and radiation) are broad-spectrum, and while in some cases it’s possible to outperform them, cytotoxic chemo and radiation are still mainstays of treatment today. The first ...