Ketamine part 2: What do in vitro studies tell us about safety?

Ketamine is an anesthetic with growing popularity as an antidepressant. As an antidepressant, it’s quite impressive. When it works, it’s often within hours- a huge improvement over giving a suicidal person a pill that might work 6 weeks from now. And it has a decent success rate in people who have been failed by several other antidepressants and are thus most in need of a new option. The initial antidepressant protocols for ketamine called for a handful of uses over a few weeks. Scott Alexander ...