Modelling the electrophysiological interactions between human pluripotent cell-derived cardiomyocite grafts and host ventricular tissue

arXiv:2605.01083v1 Announce Type: new Abstract: Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) are a promising therapy for regenerating myocardium after infarction, but their use is limited by graft-related arrhythmias that frequently occur shortly after transplantation. Experimental studies indicate that these arrhythmias can originate within the graft, which may act as an ectopic pacemaker, yet the mechanisms governing successful excitation of host tissue remain poorly understoo...