Towards A Generative Protein Evolution Machine with DPLM-Evo

arXiv:2605.00182v1 Announce Type: new Abstract: Proteins are shaped by gradual evolution under biophysical and functional constraints. Protein language models learn rich evolutionary constraints from large-scale sequences, and discrete diffusion-based protein language models~(\eg, DPLMs) are promising for both understanding and generation. However, existing DPLMs typically rely on masking-based absorbing diffusion that contradicts a simple biological intuition: proteins evolve through accumulate...