Label-Free Microrefractometry of Interfacial Processes Using Fluorescent Smart Coverslips
Hodaya Klimovsky, Amitay Ginsberg, Dmytro Ohorodniichuk, Maria Shehadeh, Ilya Olevsko, Gerardo Byk, Martin Oheim, Adi Salomon·ArXiv q-bio·Bio·
arXiv:2605.01472v1 Announce Type: cross Abstract: Molecular dipoles near interfaces emit highly directional radiation due to near-field interactions, making surface-bound fluorophores sensitive probes of local physicochemical changes. We introduce smart coverslips, stably coated with uniform, brightly fluorescent nanobead films, that exploit refractive-index-dependent emission shifts for sensitive micro-refractometry in small volumes. Supercritical-angle fluorescence refractometry uses single ba...