Alzheimer's: from causes and risk factors to models and interventions

Since the recent disappointingly small effects of monoclonal antibodies on Alzheimer's Disease (AD) progression, there has been lots of discourse around what the cause of Alzheimer's might be. "If not amyloid then what is it?", many wonder. What is the thing we have to remove? In cancer we remove cancer cells, in treating cardiovascular disease we aim to lower LDL particles and that massively lowers risk. If not amyloid, what is the LDL of Alzheimer's? In this post I argue that there is no answe...