What are the bottlenecks to safe, repeatable edits in humans? Part 1

Summary # Gene editing has made a lot of progress over the past few decades. CRISPR-Cas9 sparked the recent fervor and won some of its early pioneers a Nobel Prize, and more recently Prime Editing and Cytosine/Adenine Base Editors (CBEs/ABEs) have further expanded the range of editing targets and types of edits that are possible while increasing efficiency and reducing the rate of off-target effects. From the perspective of safe, ubiquitous editing in humans using these systems, a few major chal...