Skip to content

Normal Science

Brain healing
GraphAuthors

A reading list for frontier science

Articles across AI, biotech, forecasting, and emerging tech.

Recommendation GraphExplore who recommends whom across the networkBrowse AuthorsProfiles, influences, and key works
Weekly Digest — Free
Join researchers, founders, and analysts · Unsubscribe anytime

Categories

AllAIForecastingBioTechSecurity / OSINTMetascienceFinanceAI SafetyEnergyManufacturingCryptoStartups

Time

Sort

This Week

Will OpenAI rename to OpenSI in 2026?

Bayesian·Manifold Markets·1d ago

7% — undefined traders, $6291 volume

Will Roofcast's pilot for their property prediction platform get 50 sign ups before October 12?

daan_roofcast·Manifold Markets·1d ago

73% — undefined traders, $4123 volume

Why AI-assisted bioweapons from lone wolves and non-state actors won’t kill us all by Vasco Grilo🔸

Vasco Grilo🔸·Nuno Sempere·1d ago

[Subti­tle.] I in­ter­viewed dozens of biose­cu­rity ex­perts. The fear that AI will en­able lone wolves to build pan­demics is a case study in how do­main ex­per­tise gets sidelined.This is a cross­post for Why AI-as­sisted bioweapons won’t kill us all by Abi Olvera, which was pub­lished on Pos­i­tive Sum on 20 July 2026. Here is a re­sponse from Olivia Schar­f­man, and here is Abi’s re­ply to it.Some of my friends think we are go­ing to die be­cause AI will make build­ing a bioweapon eas­ier.T...

Will we "lose public key cryptography" by EoY 2028?

John David Pressman·Manifold Markets·2d ago

10% — undefined traders, $5560 volume

Will OpenAI retract any of its AI-Driven Mathematical Results before 2027?

Jaundiced Baboon·Manifold Markets·3d ago

99% — undefined traders, $5511 volume

Will GTA 6 be decompiled within a month of release

Jack Galler·Manifold Markets·3d ago

26% — undefined traders, $3685 volume

Will Anthropic release a new Claude Fable model before October 12, 2026?

winged_one·Manifold Markets·3d ago

4% — undefined traders, $9206 volume

Humans Are Not Chinchillas: Revisiting “How Quick and Big Would A Software Intelligence Explosion Be?” by Forethought

Forethought·Nuno Sempere·4d ago

IntroductionTom David­son and Tom Houlden’s prior model of an in­tel­li­gence ex­plo­sion poses the ques­tion: af­ter AIs can en­tirely sub­sti­tute for hu­man re­searchers at the task of im­prov­ing AI, how many year-equiv­a­lents of AI progress might be packed into a short pe­riod of time solely from fur­ther soft­ware progress, hold­ing hard­ware con­stant?In this ar­ti­cle, I build upon David­son & Houlden’s model by re­con­sid­er­ing ar­gu­ments for sev­eral pa­ram­e­ter val­ues. My chief c...

How much should we worry about the pneumonic plague lableak in Siberia? by Drew Spartz

Drew Spartz·Nuno Sempere·4d ago

Epistemic sta­tus: I wrote this up hop­ing peo­ple can poke holes in it be­cause I am quite wor­ried.Here’s what we’ve heard so far:Lo­cal me­dia is re­port­ing that an em­ployee of a BSL-3 lab in Irkutsk, Rus­sia, died of pneu­monic plague on Oct 1st.The ini­tial quaran­tine cov­ered 200 peo­ple who were in con­tact with the em­ployee be­fore she died.The FSB (Rus­sian FBI) was seen as­sist­ing in the quaran­tine, which means it was not vol­un­tary.Soviet-era whistle­blow­ers like Ken Alibek cl...

More than 1000 cases of Irkutsk Plague?

Joe and Seth·Manifold Markets·5d ago

6% — undefined traders, $15536 volume

Will the Irkutsk Anti-Plague institute incident turn into an outbreak?

Anthem·Manifold Markets·5d ago

15% — undefined traders, $4357 volume

Older

How many launches will SpaceX have in October?

Fastcar99·Manifold Markets·7d ago

What is recursive self-improvement, and what would it mean to ban it? by sarahhw

sarahhw·Nuno Sempere·7d ago

This post was origi­nally writ­ten for my Sub­stack. Please feel free to sub­scribe if this kind of con­tent in­ter­ests you!Fron­tier AI com­pa­nies have long had the stated goal of au­tomat­ing their own re­search. The de­fault plan has been to build mod­els that are even bet­ter than their most skil­led re­searchers at ad­vanc­ing the fron­tier, and let these mod­els build their own suc­ces­sors; a feed­back loop that will ul­ti­mately re­sult in su­per­in­tel­li­gence that dwarfs the col­lec...

State of the Field: AI for Epistemics and Coordination by Ben_N

Ben_N·Nuno Sempere·7d ago

1. Ex­ec­u­tive Summary1.1 What this field is and why it mattersAI is already sub­stan­tially chang­ing how peo­ple and in­sti­tu­tions work out what to be­lieve, de­cide what to do, and co­or­di­nate on ac­tions to take. As AI sys­tems be­come in­creas­ingly ca­pa­ble, they will be in­te­grated more and more in both ma­jor and day-to-day de­ci­sions.The up­side of in­volv­ing AI sys­tems in these pro­cesses could be enor­mous. AI tools for epistemics and co­or­di­na­tion could make it eas­ier t...

Will a non-lab AI-only effort solve a Millennium Problem in 2026?

Bayesian·Manifold Markets·7d ago

6% — undefined traders, $364720 volume

Will the U.S. use a nuclear weapon against Iran’s Pickaxe Mountain between November 4 and November 10, 2026?

Laurent27bis·Manifold Markets·7d ago

3% — undefined traders, $9549 volume

How many people will attend EAG NYC 2026?

d·Manifold Markets·8d ago

GPT-6.1+ Astra released in October?

Bayesian·Manifold Markets·8d ago

24% — undefined traders, $130299 volume

Will Gemini 4 Argon be released publicly before October 15

Oper_Culum·Manifold Markets·8d ago

37% — undefined traders, $9457 volume

OpenAI completes an IPO in 2027 and has a market cap of $1.5trillion+?

Jack·Manifold Markets·8d ago

64% — undefined traders, $9579 volume

US Average Gas Price on October 12 2026?

Jack·Manifold Markets·9d ago

October 2026 AI model releases

prismatic·Manifold Markets·9d ago

Trusted Deployers: Open Model Compromise by Ryan Baker

Ryan Baker·Nuno Sempere·9d ago

Cross-posted from my Sub­stack. The crit­i­cal­ity of a re­sponse to highly ca­pa­ble open mod­els is be­com­ing ur­gent, as An­thropic demon­strates the risk from the re­cent GLM-5.3 re­lease. While loss-of-con­trol is an crit­i­cal topic, this is the topic most likely to cause chaos in the next 6-12 months. If prac­tices don’t change, I’d say there’s a 50% chance that many In­ter­net based ser­vices will have to take them­selves offline for ex­tended pe­ri­ods to ad­dress se­cu­rity be­cause t...

Runtime Assurance Meets Corrigibility: What Happens When an Independent Safety Boundary Blocks an AI Agent? by Idorenyin

Idorenyin·Nuno Sempere·9d ago

This is a re­search pro­posal and re­quest for crit­i­cism. The ex­per­i­ments and bench­mark re­sults are not be­ing re­ported in this post.The re­search questionHow can a lo­cal safety layer stop an AI agent from op­er­at­ing ma­chin­ery when do­ing so would put a nearby hu­man at risk? Imag­ine an AI agent in­ter­acts with a phys­i­cal en­vi­ron­ment such as open­ing a high pres­sure valve or start­ing a mo­tor while some­one is in harm’s way, the agent re­quests an ac­tion but the safety lay...

What I learned mapping the AI safety ecosystem — and what’s missing for Africa by tjriliwan

tjriliwan·Nuno Sempere·9d ago

From Au­gust 2024 to May 2025, I worked with AI Watch, col­lab­o­rat­ing with a global team to map the AI safety land­scape — re­search­ing or­gani­sa­tions, tools, and prod­ucts, and build­ing a database of who’s do­ing what in the field.The work in­volved time-sen­si­tive liter­a­ture re­views, ex­tract­ing de­tails on labs and safety ini­ti­a­tives (from OpenAI to smaller re­search groups), and struc­tured data anal­y­sis.What sur­prised me most: how con­cen­trated the field is in the US/​UK/...

US gas prices on October 5 2026

Fastcar99·Manifold Markets·9d ago

How many people and organizations will win a 2026 Nobel Prize, all six prizes combined?

Terminator2·Manifold Markets·10d ago

Will AI Agents Pay to Avoid Killing Animals? by Jonah Woodward

Jonah Woodward·Nuno Sempere·10d ago

This ar­ti­cle was writ­ten by Jonah Wood­ward, and is a sum­mary of an origi­nal study by Com­pas­sion Aligned Ma­chine Learn­ing (CaML): Brazilek, J., Tid­marsh, M., En­dres, M., Singh, A., & Miller, J. (2026). Har­vestBench: Mea­sur­ing whether LLM agents will pay to avoid kil­ling an­i­mals. arXiv. https://​​doi.org/​​10.48550/​​arXiv.2609.04444 You can view the up-to-date re­sults for Har­vestBench on the leader­board at https://​​com­pas­sion­bench.com/​​har­vest­bench TL;DRHar­vestBench e...

US Average Gas Price Is $4.3800 or more on October 5 2026?

Jack·Manifold Markets·10d ago

10% — undefined traders, $39892 volume

Wastewater monitoring as an early warning for pandemics (A Happier World video) by Jeroen Willems🔸

Jeroen Willems🔸·Nuno Sempere·11d ago

After more than two years, I have fi­nally pub­lished a new A Hap­pier World video!This time I ex­plored the con­nec­tion be­tween a hid­den river in Brus­sels, a visit by Bill Gates to the city’s sew­ers, and pan­demic pre­ven­tion.I in­ter­viewed @Jeff Kauf­man 🔸 and @Will Brad­shaw from Se­cureBio De­tec­tion (formerly the Nu­cleic Acid Ob­ser­va­tory), peo­ple work­ing at Scien­sano (es­sen­tially the CDC of Belgium), and some­one from the Brus­sels Sewer Mu­seum. Would love to hear what yo...

What percentage will Gallup report as bisexual among U.S. adults age 18–29 in its 2026 data?

Jacob·Manifold Markets·11d ago

Evidence about risk should be transparent by Ajeya

Ajeya·Nuno Sempere·11d ago

Note: This post was cross­posted from Planned Ob­so­les­cence by the Fo­rum team, with the au­thor’s per­mis­sion. The au­thor may not see or re­spond to com­ments on this post.Subti­tle: We can’t de­velop safety stan­dards if we have to rely on opaque judgmentAll views are my own and do not rep­re­sent my em­ployer.In the wake of the re­cent wave of mis­al­ign­ment in­ci­dents, both OpenAI and An­thropic have re­ported slow­ing down RL train­ing to im­prove safety. Th­ese in­ci­dents, com­bined...

What results will happen during week 5 of the College Football Season

TheDucksFan·Manifold Markets·12d ago

Will my flight be delayed | will I miss my connection?

Genzy·Manifold Markets·12d ago

Will one AI lab pull ahead before 2028?

SG·Manifold Markets·13d ago

28% — undefined traders, $6120 volume

What will be announced at OpenAI DevDay 2026?

Bayesian·Manifold Markets·13d ago

Gas prices in the US on September 30 2026?

Fastcar99·Manifold Markets·15d ago

State of Pandemic Early Warning by Jeff Kaufman 🔸

Jeff Kaufman 🔸·Nuno Sempere·15d ago

This lightly-ed­ited ver­sion of a memo that I pre­sented at the Sum­mer 2026 Biose­cu­rity Sum­mit out­side of DC. While oth­ers at Se­cureBio of­ten see things similarly, I’m at­tempt­ing to pre­sent my view and not a Se­cureBio “house view”.The GoalWe need to be ro­bust to ad­ver­saries who want to cause very large-scale harm with biol­ogy. This in­cludes ac­tors (hu­man or AI) who want to kill all hu­mans, cause short-term in­ca­pac­i­ta­tion or long-term civ­i­liza­tional col­lapse, or who ...

Will Opus 5.5 get nerfed within a week of launch?

Hi·Manifold Markets·15d ago

4% — undefined traders, $1032 volume

Which Frontier AI Lab will hold the #1 spot on Chatbot Arena on October 1?

Avatar·Manifold Markets·15d ago

AI safety field *visual* impact analysis by hannarchy

hannarchy·Nuno Sempere·15d ago

I made a ter­rain style vi­su­al­i­sa­tion of AI safety im­pact of around 3,466 works or­ganised by cita­tion count! The data was ex­tracted from Arxiv and LessWrong posts based on a dic­tio­nary of key­words that ap­pear in AI safety works. Ad­di­tion­ally, I think its im­por­tant to see how the field has “evolved” over time so I added a time func­tion­al­ity to slide and see the hills form­ing.The map is based on how par­tic­u­lar works over­lap based on em­bed­ding space level clus­ter­ing or...

US Average Gas Price Is $4.4800 or more on September 28 2026?

Jack·Manifold Markets·15d ago

18% — undefined traders, $11768 volume

US Average Gas Price Is $4.4900 or more on September 29 2026?

Jack·Manifold Markets·16d ago

2% — undefined traders, $10650 volume

Will Anthropic’s IPO S-1 be public by 16 October 2026?

jim·Manifold Markets·16d ago

30% — undefined traders, $12638 volume

Will the top Artificial Analysis Intelligence Index score reach 60 or higher on September 24, 2026?

Bumin Anlakoğlu·Manifold Markets·16d ago

1% — undefined traders, $1089 volume

The 72% problem: what reward hacking benchmark suggests about disposition vs environment in AI governance by Rhea

Rhea·Nuno Sempere·17d ago

Kun­var Thaman’s Re­ward Hack­ing Bench­mark: Mea­sur­ing Ex­ploits in LLM Agents Tool Use (https://​​arxiv.org/​​abs/​​2605.02964) eval­u­ates 13 fron­tier mod­els on multi-step, tool-use tasks that each con­tain a built-in short­cut: skip­ping a ver­ifi­ca­tion step, in­fer­ring an an­swer from meta­data rather than do­ing the task, or tam­per­ing with a func­tion the eval­u­a­tion it­self de­pends on.The find­ing I keep com­ing back to: in 72% of the re­ward hack­ing epi­sodes recorded, the m...

US Average Gas Price Is $4.3500 or more on September 28 2026?

Jack·Manifold Markets·18d ago

99% — undefined traders, $15116 volume

US Average Gas Price Is $4.4500 or more on September 24 2026?

Jack·Manifold Markets·18d ago

98% — undefined traders, $12573 volume

Bitcoin $87,500 in September 2026?

Jack·Manifold Markets·18d ago

1% — undefined traders, $36332 volume

Will the recorded US measles cases reach or exceed 3,500 cases in today's update?

dfish·Manifold Markets·21d ago

99% — undefined traders, $10195 volume